沈雷

笔者:bck体育网页版 发布时间:2019.01.16 14:49
  

姓名:沈雷  

性别:男    

出生年月:19832

学位: 博士     

职称: 教授,博士生导师

Emailleishen@whut.edu.cn

 

教育经历:

2003-2008,中国科学技术大学 & University of Toronto,博士(联培),导师:吴奇 院士 & Prof. Mitchell A. Winnik

1999-2003,中国科学技术大学,化学物理系,本科

 

研究经历:

2017-今,bck官网,化学化工与生命科学BCKBET,教授

2013-2016,华中科技大学,化学与化工BCKBET,副教授

2012-2013,美国 Columbia University,化学系,助理研究员

2009-2012,美国 The University of Texas at Austin & University of Minnesota,博士后,合作导师:Prof. Xiaoyang Zhu & Prof. Timothy Lodge

2008-2009,瑞士University of Geneva,博士后,合作导师:Prof. Michal Borkovec

 

研究领域:

课题组聚焦大分子表界面的基础研究,利用化学物理手段解决与表界面相关的重要科学问题,设计界面材料。

招收研究生方向:物理化学、材料、高分子、无机、有机化学等。

近年来培养的研究生获国家一等奖学金和学校一等奖学金。欢迎化学、物理、材料相关学科的本科生和研究生加入课题组。

 

主要科研项目:

1.     国家自然科学基金面上项目,糖脂双层膜界面在阿尔茨海默病Abeta肽聚集中的作用研究,2016-201980万元,主持;

2.     国家自然科学基金青年项目,流感病毒HA蛋白质与糖的多价相互作用研究,2015-201725万元,主持;

3.     bck官网"15551"青年拔尖人才。

 

代表性论文:

在化学学科ESI领域权威期刊上共发表SCI论文50篇,包括化学领域内顶尖期刊J. Am. Chem. Soc.MacromoleculesLangmuir等,被SCI他引1200余次,并在国际权威胶体界面化学综述期刊Adv. Colloid Interface Sci.撰写综述。

 

1.     S. Gong, J. Liu, M. Tian, K Wang, S. Cai, W. Wang, Lei Shen*, Unravelling the mechanism of amyloid-β peptide oligomerization and fibrillation at chiral interfaces. Chem. Commun., 2019, DOI: 10.1039/C9CC06980A.

2.     J. Lin, K. Wang, X. Xia, Lei Shen*. Quantification of Multivalency in Protein Oligomer Coated Nanoparticles Targeting Dynamic Membrane Glycan Receptors. Langmuir, 2018, 34, 8415-8421.

3.     M. Yang, K. Wang, J. Lin, L. Wang, F. Wei*, J. Zhu, W. Zheng, Lei Shen*. Gel phase membrane retards amyloid beta-peptide (1-42) fibrillation by restricting slaved diffusion of peptides on lipid bilayers. Langmuir, 2018, 34, 8408-8414.

4.     K. Wang, Y. Chen, X. Gong, J. Xia, J. Zhao*, Lei Shen*. A mobile precursor determines protein resistance on nanostructured surfaces. Phys. Chem. Chem, Phys., 2018, 20, 12527-12534.

5.     K. Shezad, K. Zhang, M. Hussain, H. Dong, C. He, X. Gong, X. Xie, J. Zhu*, Lei Shen*. Surface roughness modulated diffusion and fibrillation of amyloid-beta peptide. Langmuir, 2016, 32, 8238-8244.

6.     Lei Shen, Y. Wang, C. Lin, H. Liu*, A. Guo*, X. Y. Zhu*. Membrane environment can enhance the interaction of glycan binding protein to cell surface glycan receptors. ACS Chem. Biol., 2014, 9, 1877-1884.

7.     Lei Shen, T. Adachi, D. Vanden Bout, X. Y. Zhu*. A mobile precursor determines amyloid-beta peptide fibril formation at interfaces. J. Am. Chem. Soc., 2012, 134, 14172-14178.

 

获奖与荣誉:

湖北省楚天学者计划(楚天学子)2015年,高分子化学与物理

 

Prof. Lei Shen

Tel: +86-15926376089

Email: leishen@whut.edu.cn

 

Education

2003   B. Sc.    University of Science & Technology of China

2008   Ph.D.    University of Science & Technology of China

 

Position

Since 2017    Professor, Wuhan University of Technology

2014-2016    Associate Professor, Huazhong University of Science and Technology

2012-2013    Associate Research Scientist, Columbia University, USA

2009-2012    Research Associate, The University of Texas at Austin, USA

2009-2009    Research Associate, University of Minnesota, USA

2008-2009    Research Associate, University of Geneva, Switzerland

 

Research Interests

Our research interests focus on macromolecules at surfaces and bio-interface phenomena, including:

1.  nucleation and fiber formation of neuro-degenerative diseases related proteins and peptides at surfaces;

2.  molecular characteristic properties of polymers at surfaces;

3.  multivalent interactions at bio-interfaces;

4.  design, synthesis and modification of interfacial materials

 

Representative Publications

1.  S. Gong, J. Liu, M. Tian, K Wang, S. Cai, W. Wang, L. Shen*, Unravelling the mechanism of amyloid-β peptide oligomerization and fibrillation at chiral interfaces. Chem. Commun., 2019, DOI: 10.1039/C9CC06980A.

2.  J. Lin, K. Wang, X. Xia, L. Shen*, Quantification of multivalency in protein oligomer coated nanoparticles targeting dynamic membrane glycan receptors. Langmuir, 2018, 34, 8415-8421.

3.  M. Yang, K. Wang, J. Lin, L. Wang, F. Wei*, J. Zhu, W. Zheng, L. Shen*. Gel phase membrane retards amyloid beta-peptide (1-42) fibrillation by restricting slaved diffusion of peptides on lipid bilayers. Langmuir, 2018, 34, 8408-8414.

4.  K. Wang, Y. Chen, X. Gong, J. Xia, J. Zhao*, L. Shen*. A mobile precursor determines protein resistance on nanostructured surfaces. Phys. Chem. Chem, Phys., 2018, 20, 12527-12534.

5.  K. Shezad, K. Zhang, M. Hussain, H. Dong, C. He, X. Gong, X. Xie, J. Zhu*, L. Shen*. Surface roughness modulated diffusion and fibrillation of amyloid-beta peptide. Langmuir, 2016, 32, 8238-8244.

6.  L. Shen, Y. Wang, C. Lin, H. Liu*, A. Guo*, X. Y. Zhu*. Membrane environment can enhance the interaction of glycan binding protein to cell surface glycan receptors. ACS Chem. Biol., 2014, 9, 1877-1884.

7.  L. Shen, T. Adachi, D. Vanden Bout, X. Y. Zhu*. A mobile precursor determines amyloid-beta peptide fibril formation at interfaces. J. Am. Chem. Soc., 2012, 134, 14172-14178.

 

 

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