徐文瑨

笔者:bck体育网页版 发布时间:2019.01.16 15:43
  
  姓名:徐文瑨简介
   性别:男

  出生年月:1974年4月

  学位:博士

  职称与职位:副教授

  电话:18064106107

  E-Mail:wjxu@whut.edu.cn

  教育经历 

  2008年在武汉大学获得有机化学博士学位。

  科研学术工作经历 

  2009年11月-2010年10月于美国爱荷华大学,博士后研究,研究课题:单糖衍生化及单糖分子印迹材料研究及环境污染物及代谢产物(PCBs)合成研究;2010年11月-2013年7月于美国威斯康星大学麦迪逊分校, 研究助理,研究课题:基于癌症的早期诊断和靶向治疗的纳米材料的研究。2014年4月至今,bck官网bck体育制药工程系, 硕士研究生导师。

  研究领域 

  主要研究方向为生物药用高分子材料的基础理论研究及其在生物医学和生物技术领域的应用,包括药物控制释放、疾病诊断、基因治疗等;药物合成研究。

  教学、科研概况 

  教学方面主要承担有药学专业课程及实验教学工作,开设有药剂学、医药文献检索与利用、药物治疗学及药物发展史等课程。科研方向为:1)基于纳米医学技术的癌症早期诊断和治疗;2)药物的靶向传输及控制释放研究。此方向为目前热门研究领域且应用性强。本课题组具备独立开展相关科研研究的实验条件,并与美国威斯康星大学麦迪逊分校、密西根大学、爱荷华大学及武汉大学等国内外著名高校有紧密的合作交流。

  主持的主要科研项目 

  1. bck官网博士科研启动费,471/40120176、多功能纳米体系的合成及其在肿瘤靶向与早期诊断中的应用研究、2014/09-2016/09、30万。

  2. 湖北省自然科学基金面上项目,2016CFB587,前列腺癌诊断治疗一体化纳米体系的合成与应用研究,2016/01-2017/12,3万元,在研,主持。

  3. 国家自然科学基金面上项目,51572206,具有电刺激作用的三维梯度β-TCP复合神经导管材料的研究,2016/01-2019/12,76.8万,在研,参与。

  近年代表性论文 

  1. Jia Yang, Weifei Lu, Jinling Xiao, Qi Zong, Haixing Xu, Yihua Yin, Hao Hong*, Wenjin Xu**. A Positron Emission Tomography Image-Guidable Unimolecular Micelle Nanoplatform for Cancer Theranostic Applications. Acta Biomaterialia, 2018, 79, 306-316.

  2. Renata Jaskula-Sztul#, Wenjin Xu#, Guojun Chen, April Harrison, Ajitha Dammalapati, Renu Nair, Yiqiang Cheng, Shaoqin Gong, Herbert Chen. Thailandepsin A-?loaded and octreotide-?functionalized unimolecular micelles for targeted neuroendocrine cancer therapy. Biomaterials, 2016, 91, 1-10. (并列第一作者)

  3. Wenjin Xu, Imtiaz Siddiqui, Minakshi Nihal, Srikanth Pilla, Kimberly Rosenthal,

  Hasan Mukhtar, and Shaoqin Gong. Aptamer-conjugated and doxorubicin-loaded unimolecular micelles for targeted therapy of prostate cancer. Biomaterials, 2013, 34, 5244-5253.

  4. Wenjin Xu, Jocelyn F. Burke, Srikanth Pilla, Herbert Chen, Renata Jaskula-Sztul, and Shaoqin Gong. Octreotide-functionalized and Resveratrol-loaded unimolecular micelle for targeted medullary thyroid cancer therapy. Nanoscale, 2013, 5, 9924-33.

  5. Wenjin Xu, Xianran He, Min Zhong, Xianming Hu, Yuling Xiao*. A novel pH-responsive hydrogel based on natural polysaccharides for controlled release of protein drugs. RSC Adv., 2015, 5 (5), 3157 – 3167.

  6. Wenjin Xu, Gifty Osei-Prempeh, Carolina Lema, E. Davis Oldham, Renato J. Aguilera, Sean Parkin, Stephen E. Rankin, Barbara L. Knutson, Hans-Joachim Lehmler. Synthesis, thermal properties, and cytotoxicity evaluation of hydrocarbon and fluorocarbon alkyl β-D-xylopyranoside surfactants. Carbohydrate Research, 2012, 349, 12-23.

  7. Wenjin Xu, Hao Guo, Qifeng Zhu, Xianbing Ke, Xianming Hu. Asymmetric Borane Reduction of Prochiral Ketones Catalyzed by α,α-Disubstituted   Aziridine- methanols. Catalysis Letters, 2008, 125, 302-307.

  8.Wenjin Xu, Hao Guo, Jun Zhang, Qifeng Zhu, Xianming Hu. Asymmetric reduction of acetophenone using α,α-disubstituted aziridinemethanols and borane. Journal of Molecular Catalysis A: Chemical, 2009, 300, 25-28.

  9. Wenjin Xu, Jun Zhang, Hao Guo, Qifeng Zhu and Xianming Hu. The influence of substituents on the hydroxyl-bearing carbon in the aza-Payne rearrangement of aziridinemethanols. Letters in Organic Chemistry, 2009, 6, 412-415.

  10. Alireza Javadi,?Yuling Xiao,?Wenjin Xu and Shaoqin Gong. Chemically modified graphene/P (VDF-TrFE-CFE) electroactive polymer nanocomposites with superior electromechanical performance. J. Mater. Chem., 2012,?22, 830-834.

  11.Yuling Xiao, Hong Hao, Alireza Javadi, Jonathan W. Engle, Wenjin Xu, Yunan Yang, Yin Zhang, Todd E. Barnhart, Weibo Cai and Shaoqin Gong. Multifunctional unimolecular micelles for cancer-targeted drug delivery and positron emission tomography imaging. Biomaterials, 2012, 33, 3071-3082.

  12. Yuling Xiao,?Renata Jaskula-Sztul,?Alireza Javadi,?Wenjin Xu,?Jacob Eide, Ajitha Dammalapati,?Muthusamy Kunnimalaiyaan, Herbert Chen and Shaoqin Gong. Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy. Nanoscale, 2012, 4, 7185-7193.

  13. Yuling Xiao, Hao Hong, Vyara Z. Matson, Alireza Javadi, Wenjin Xu, Yunan Yang, Yin Zhang, Jonathan W. Engle, Robert J. Nickles, Weibo Cai, Douglas A. Steeber, and Shaoqin Gong. Gold nanorods conjugated with doxorubicin and cRGD for combined anticancer drug delivery and PET imaging. Theranostics.2012, 2, 757-768.

  14. Yuling Xiao, Wenjin Xu, Qifeng Zhu, Bingfang Yan, Jin Yang, Xianran He, Shucai Liang, Xianming Hu. Preparation and Characterization of a Novel Pachyman-Based Pharmaceutical aid II. A pH-Sensitive, Biodegradable and Biocompatible Hydrogel for Controlled Release of Protein Drugs. Carbohydrate Polymers, 2009, 77, 612-620.

  15. Xianbing Ke, Hao Hu, Wenjin Xu, Qifeng Zhu, Xianming Hu. Significant steroids: effective and general synthesis of 4α- and 4β-amino-5α-androstanes. Chemical Communications, 2009, 9, 1037-1039.

  16. Xianbing Ke, Hao Hu, Wenjin Xu, Qifeng Zhu, Xianming Hu. A facile and general synthesis of 2β-aminosteroids. Synthesis, 2009, 8, 1255-1260.

  17. Zhigang Xiong, Qi Wei, Hanmei Chen, Wenjin Xu, Guofu Qiu, Shucai Liang, Xianming Hu. Microbial Transformation of Androst-4-ene-3,17-dione by Beauveria Bassiana. Steroids, 2006, 71, 979-983.

  18. Qifeng Zhu, Yuanhu Pan, Zaixu Xu, Ruiming Li, Guofu Qiu, Wenjin Xu, Xianbing Ke, Lamei Wu, Xianming Hu. Synthesis and potential anticonvulsant activity of new N-3-substituted 5,5-cyclopropanespirohydantoins. European Journal of Medicinal Chemistry, 2009, 44, 296-302.

  

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