郑化

笔者:bck体育网页版 发布时间:2019.01.17 09:34

 

  姓名:郑化   

  性别:   

  出生年月: 19659 

  学位:博士

  职称:教授、博导 

  联系电话:     

  Emailzhenghua.whut@126.com 

    

  教育经历: 

  1982-1986年 北京师范大学化学系化学专业学习,获理学学士学位 

  1994-1996年 原武汉汽车工业大学高分子化工专业学习、获工学硕士学位 

  1998-2001年 武汉大学环境科学专业天然高分子研究方向学习、获工学博士学位  

  工作经历: 

  1986-2000年 原武汉汽车工业大学化学工程系助教、讲师、副教授 

  2001-2012年 bck官网化学工程系教授(博士生导师)、系副主任、系主任、bck官网化学工程BCKBET院长、湖北省中药制剂工程技术研究中心主任、bck官网材料研究保护研究所所长 

  研究领域: 

  一、功能化合物的合成与工艺 

  二、生物医用材料及其制备新技术 

  三、药用新剂型与制备新技术 

  近年主持的主要科研项目: 

  1、基于Cathepsin X 响应的抗慢性淋巴白血病主动靶向控释纳米给药系统的构建与评价,国家自然科学基金(项目编号51273156 

  2pH敏感羧甲基甲壳糖纳米粒的制备及其结肠定位给药系统研究,国家自然科学基金(项目编号50503019 

  3、抗急性髓系白血病药物巯嘌呤的控释靶向纳米给药系统的构建与评价,国家自然科学基金(项目编号50973088 

  4、新型功能化合物的研制等年度项目、专项多项,国家工信部 

  5、巯嘌呤类抗恶性肿瘤药物控释靶向纳米制剂的设计、制备与应用研究,湖北省自然科学基金重点项目(项目编号2010CDA040 

  6、甲壳生物废弃物的绿色与综合利用关键技术研究,湖北省国际科技合作项目(项目编号2010BFA021 

  7、结肠用羧甲基壳聚糖缓控释凝胶新辅料开发,湖北省重点科技攻关项目(2006AA301B17 

  8、由甲壳动物废弃物制备2-脱氧-D-葡萄糖工艺研究与产品开发,浙江省重大科技关项目(2004E30015) 

  9、壳聚糖仿生皮肤的研制,湖北省重点科技计划项目(2003AA303B09 

  10双表型混合性白血病化疗药物主动靶向纳米制剂的设计、制备与应用研究 

  11、慢性淋巴细胞白血病智能靶向纳米给药系统的构建与评价,武汉市学科带头人计划(项目编号201271130436 

  12、基于壳聚糖衍生物的智能释药肝靶向纳米传递系统的构建,武汉市重大创新专项(项目编号20091j0001) 

  13、盐酸氨基葡萄糖产业化工艺的研究与开发,企业委托 

  14、硫酸氨基葡萄糖产业化工艺的研究与开发,企业委托 

  15 智能药物控释水凝胶的研究,企业委托 

  近年代表性论文与专利: 

  1Jiaxing Hu, Qin Hua-Li, Xu Wengang, Li Junli, Zhang Fanglin, Zheng Hua. TfOH-catalyzed synthesis of 3-aryl isoindolinones via a tandem reaction [J]. Chem. Commun., 2014, 50(99): 15780-15783. 

  2D. Li, Lu B., Huang Z., Xu P., Zheng H., Yin Y., Xu H., Liu X., Chen L., Lou Y., Zhang X., Xiong F. A novel melphalan polymeric prodrug: preparation and property study [J].Carbohydr Polym, 2014, 111:928-935. 

  3Chuxiang Sun, Shu Ke, Wang Wei, Ye Zhao, Liu Ting, Gao Yuxiang, Zheng Hua, He Guanghua, Yin Yihua. Encapsulation and controlled release of hydrophilic pesticide in shell cross-linked nanocapsules containing aqueous core [J]. Int. J. Pharm., 2014, 463(1): 108-114. 

  4Cheng Gao, Liu Ting, Dang Yinghua, Yu Zhiyan, Wang Wei, Guo Jingjing, Zhang Xueqiong, He Guanghua, Zheng Hua, Yin Yihua, Kong Xiangqi. pH/redox responsive core cross-linked nanoparticles from thiolated carboxymethyl chitosan for in vitro release study of methotrexate [J]. Carbohydrate Polymers, 2014, 111: 964-970. 

  5Bo Lu, Huang Dan, Zheng Hua, Huang Zhijun, Xu Peihu, Xu Haixing, Yin Yihua, Liu Xia, Li Dan, Zhang Xueqiong. Preparation, characterization, and in vitro efficacy of O-carboxymethyl chitosan conjugate of melphalan [J]. Carbohydr. Polym., 2013, 98(1): 36-42. 

  6Yihua Yin, Sha Xu, Dan Chang,Hua Zheng, Junli Li, Xiaoping Liu, Peihu Xu, Fuliang Xiong. One-pot synthesis of biopolymeric hollow nanospheres by photocrosslinking.  Chemical Communications, 2010, 46(43): 8222-8224. 

  7Xiaoyu Gong, Yihua Yin, Zhijun Huang, Bo Lu, Peihu Xu, Hua Zheng, Fuliang Xiong. Preparation, characterization, and in vitro release study of a glutathione-dependent polymeric prodrug cis-3-(9H-purin-6-ylthio)-acrylic acid-graft-carboxymethyl chitosan.International Journal of Pharmaceutics2012436: 240-247. 

  8Bo Lu, Xu Liu, Zhijun Huang, Haixing Xu, Peihu Xu, Yiting Wang, Hua Zheng, Yihua Yin, Xianzheng Zhang, Renxi Zhuo. Synthesis of diamine maleyl chitosans, and in vitro transfection studies. Carbohydrate Polymers, 2012, 87, 1453-1459. 

  9He Guanghua, Wang Zi, Zheng Hua, Yin Yihua, Xiong Xiong. Preparation, characterization and properties of aminoethyl chitin hydrogels. Carbohydrate Polymers, 2012, 90, 1614-1619. 

  10Houwei Tu, Yi Qu, Xiaohua Hu, Yihua Yin, Hua Zheng, Peihu Xu, Fuliang Xiong. Study of the sigmoidal swelling kinetics of carboxymethylchitosan-g- poly(acrylic acid) hydrogels intended for colon-specific drug delivery. Carbohydrate Polymers, 2010,82440-445. 

  11Yihua Yin, Xianglan Lv, Houwei Tu, Sha Xu, Hua Zheng. Preparation and swelling kinetics of Ph-sensitive photocrosslinked hydrogel based on carboxymethyl chitosan. Journal.of Polymer Research2010, 17: 471-479. 

  12Lu B, Wu DQ, Zheng H, Quan CY, Zhang XZ, Zhuo RX. Galactosyl conjugated N-succinyl-chitosan-graft-polyethylenimine for targeting gene transfer. Molecular BioSystems2010, 6, 2529-2538. 

  13 Hua Zheng, Yan Rao, Yihua Yin, Xiong Xiong, Peihu Xu, Bo Lu. Preparation, characterization, and in vitro drug release behavior of 6-mercaptopurine carboxymethyl chitosan. Carbohydrate Polymers, 2011, 83:1952-1958. 

  14)Hua Zheng,Xueqiong Zhang, Fuliang Xiong, Zhongjia Zhu, Bo Lu, Yihua Yin, Peihu Xu, Yumin Du. Preparation, characterization, and tissue distribution in mice of lactosaminated carboxymethyl chitosan nanoparticles. Carbohydrate Polymers, 2011, 83:1139-1145. 

  15Hua Zheng, Xueqiong Zhang, Yihua Yin, Fuliang Xiong, Xiaoyu Gong, Zhongjia Zhu, Bo Lu, Peihu Xu. In vitro characterization, and in vivo studies of crosslinked lactosaminated carboxymethyl chitosan nanoparticles. Carbohydrate Polymers, 2011, 84:1048-1053. 

  16Ying Yi, Sha Xu, Haikuan Sun, Dan Chang, Yihua Yin, Hua Zheng, Haixing Xu, Yiceng Lou. Gelation of photocrosslinkable carboxymethyl chitosan and its application in controlled release of pesticide. Carbohydrate Polymers,2011,86:1007-1013. 

  17Bo Lu, Xu Liu, Zhijun Huang, Haixing Xu, Peihu Xu, Yiting Wang, Hua Zheng, Yihua Yin, Xianzheng Zhang, Penxi Zhuo. Synthesis of diamine maleyl chitasans, and in vitro transfection studies. Carbohydrate Polymers, 2012,87:1453-1459. 

  18Dan Chang, Jing Lei, Huiran Cui, Na Lu, Yanjuan Sun, Xiaohua Zhang, Cheng Gao, Hua Zheng, Yihua Yin.Disulfide cross-linked nanospheres from sodium alginate derivative for inflammatory bowel disease: Preparation, characterization, and in vitro drug release behavior.Carbohydrate Polymers, 2012,88:663-669. 

  19Ling Kai, Zheng Fei, Li Junli, Tang Rupei, Huang Jin, Xu Yongmei, Zheng Hua, Chen Jinghua. Effects of substitution degree of photoreactive groups on the properties of UV-fabricated chitosan scaffold. Journal of Biomedical Materials Research Part A, 2008, 87(1): 52-61. 

  20Xu Yong Mei, Zhan Chang You, Fan Li Hong, Wang Le, Zheng Hua. Preparation of dual crosslinked alginate-chitosan blend gel beads and in vitro controlled release in oral site-specific drug delivery system. International Journal of Pharmaceutics. 2007, 336 (2): 329-337. 

     

  (1)生物质化工与生物质材料,化学工业出版社,20098月,主编。 

  主要奖励与荣誉 

  (1)基于分散片剂型两种中药新药的创制与产业化,湖北省科技进步一等奖,2012年; 

  (2) 2-脱氧-D-葡萄糖的生产新工艺与技术,湖北省科技进步二等奖,2008年; 

  (3) 新型负压封闭引流生物海绵材料的研发及产业化,湖北省科技进步二等奖,2012年; 

  (4) 复方夏枯草微囊型缓释胶囊的工艺研究,湖北省科技进步三等奖,2009年。 

附件下载:   
XML 地图 | Sitemap 地图