吴建平

笔者:bck体育网页版 发布时间:2019.03.11 08:44


姓名:吴建平    

性别:    

出生年月:196811 

学位:博士    

职称:bck体育网页版,教授 

联系电话:18062552085       Emailbiojpwu@whut.edu.cn   biojpwu@qq.com

教育经历: 

  1994/09 1997/07 武汉同济医科大学,预防医学,博士

  1991/09 1994/07 武汉同济医科大学,预防医学,硕士

  1986/09 1991/07 武汉同济医科大学,环境医学,学士

研究经历: 

2018/03  至今  bck官网,化学化工与生命科学BCKBET,教授

2012/03- 2018/03 Virginia Tech Carilion School of Medicine, Assistant Professor

2009/102012/03 Washington University in St. Louis, Sr. Scientist

2003/072009/10 University of Alabama at Birmingham, Research Associate

1999/072003/07 Georgia State University, Post-Doc Research Associate 

研究领域: 

1)  脑血管病:侧重于脑功能保护基础研究及药物研发; 

2)  中枢神经网络的代谢性调控与癫痫:难治性癫痫发病机制、抗癫痫药物筛选。

主要科研项目: 

1)  ITPKA/IP4PI3K/AKT信号途径交互调控NBCs活性引发脑缺血再灌注迟发性神经元死亡机制研究”, 主持, 国家自然科学基金(81870935) 20192023

2)  “神经药理基础与创新”,主持,bck官网,2018年~2023 

代表性论文与专利: 

1)    Martinez Pedro*, Wu J*, Yang CT, Liang HW, Xia XM, Lingle CJ.  Genetic deletion of SLO2.2 enhances itch sensing, abolishes Na+ activated K+ current, and increases action potential firing frequency in DRG neurons. Elife. 2015 Nov 11;4. pii: e10013. doi: 10.7554/eLife.10013  (*contributed equally)

2)    Thornell IM, Wu J, Liu XF, Bevensee MO. PIP2 hydrolysis stimulates electrogenic Na/bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus laevis oocytes. J Physiol. 2013 Dec 1;590(Pt 23):5993-6011

3)    Wang W, Wu J, Bernard K, Bevensee MO and Kirk K. CFTR channel activation: constitutive mutants and allosteric modulation by phosphorylation. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3888-93. Epub 2010 Feb 3.

4)    Wu J, McNicholas CM, Bevensee MO. PIP2 modulation electrogenic Na/bicarbonate cotransporter (NBCe1). Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14150-5. Epub 2009 Aug 10.

5)    Rojas A*, Wu J*, Wang R, Jiang C. Gating of the ATP-sensitive K(+) channel by a pore-lining phenylalanine residue.  Biochim Biophys Acta- Biomembranes. 2007 Jan: 1768 (1): 39-51

6)    Wu J, Hablitz JJ. Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons.     J Neurosci. 2005 Jul 6;25(27):6322-8.

7)    Wu J*, Wang R*, Rojas A*, Piao H, Adams CY, Xu H, Shi Y, Wang Y, Jiang C. Determinant role of membrane helices in KATP channel gating. J Membr Biol. 2005 Mar;204(1):1-10. (* contributed equally).

8)    Wu J, Piao H, Rojas A, Wang R, Wang Y, Cui N, Shi Y, Chen F and Jiang C.  Critical membrane helical domains and amino acid residues in gating Kir6.2 channels by intracellular ATP. J Cell Physiol. 2004 Jan;198(1):73-81

9)    Wu J, Xu H, Shen W and Jiang C. Expression and co-expression of  CO2- sensitive Kir Channels in brainstem neuron of rats. J Membr Biol. 2004 Feb 1;197(3):179-91 

10) Li L, Wu J and Jiang C. Differential expression of Kir6.1 and SUR2B mRNA in Vasculatures of various tissues in rats.  J Membr Biol. 2003 Nov 1;196(1):61-9

11) Wang X, Wu J, Li L, Chen F, Wang R and Jiang C. Hypercapnic acidosis activates KATP channels in vascular smooth muscles.  Circ Res. 2003 Jun 13;92(11):1225-32

12) Cui N*, Wu J*,  Xu H*, Wang R, Rojas A, Piao H, Mao J, Abdulkadir L, Li L, Jiang C. Threonine residue (Thr71) plays a critical role in the gating of Kir6.2 channel by intracellular ATP and pH.  J Membr Biol. 2003 Mar 15;192(2):111-22.

13) Mao J, Wu J, Fuxue Chen, Xueren Wang and Chun Jiang. Inhibition of G-protein Coupled Inward Rectifying K+ Channels by Intracellular Acidosis.  J Biol Chem. 2003 Feb 28;278(9):7091-8. Epub 2002 Dec 25.  

14) Wu J, Cui, N., Piao, H., Wang, Y., Xu, H., Mao, J. and Jiang, C. Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP.  J  Physiol. 2002 Sep 1;543(Pt 2):495-504

15) Wu J, Xu H., Yang Z., Wang Y, Mao J and Jiang C. Protons activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures. J Membr Biol. 2002 Nov 15;190(2):105-16.  

16) Xu H, Wu J, Cu, N, Abdulkadir L, Wang R, Mao J, Giwa LR, Chanchevalap S and Jiang C. Distinct histidine residues control the acid-induced activation and inhibition of the cloned KATP channel. J Biol Chem. 2001 Oct 19;276(42):38690-6. Epub 2001 Aug 20

 

  学术奖励及荣誉: 

  National Alliance for Research on Schizophrenia and Depression”                 Young Investigator Award (NARSD, 2006)
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